I doubt it, but I'm not really sure. You might want to ask a Vet, or look up poisonous plants. Around here, squirrels devour the seeds, chewing the pods to pieces trying to get the seeds out. Doesn't seem to hurt them. Also, another source says that birds eat them. I've never seen that happen, but can't say it doesn't. One source does indicate that the bark (of the tree, not the dog) can be irritating - don't ask me how. It is also said that parts of the tree are used for medicinal purposes. I don't know which parts, and I would never dare to experiment. Supposedly, some parts of the magnolia tree have been used for medicinal purposes."